Canine distemper is a kind of acute febrile infectious disease caused by canine distemper virus (CDV), which is highly infectious and has a mortality rate of more than 80%. It can infect a variety of domestic and wild animals. It can lead to lymphocytopenia and prolonged immunosuppression, and is prone to secondary infections. The clinical symptoms of the dog were fever, catarrhal respiratory symptoms, gastrointestinal disease, rash, and central nervous system disease.