Adenovirus can cause a variety of diseases, the most common are infant acute respiratory infection, adenovirus pneumonia, epidemic keratoconjunctivitis, pharyngeal conjunctivitis, other diseases such as infant diarrhea, hemorrhagic cystitis, myocarditis, meningitis and so on.

Adenovirus can infect respiratory tract, gastrointestinal tract, urinary tract and bladder, eye, liver, etc. About 1/3 of the known serotypes of human adenovirus are usually associated with human disease, but one serotype can cause different clinical diseases. On the contrary, different serotypes can also cause the same disease.